MK2- and HuR–dependent translational regulation of TTP mRNA.
- Christopher Tiedje (131407)
- Natalia Ronkina (131409)
- Mohammad Tehrani (131411)
- Sonam Dhamija (131413)
- Kathrin Laass (131415)
- Helmut Holtmann (131418)
- Alexey Kotlyarov (131419)
- Matthias Gaestel (131424)
Publication date
September 2012
DOIAbstract
<p>A) Cytosolic polysomal profiles for TTP mRNA of LPS-stimulated MK2-rescued and GFP-transduced macrophages. B) Cytosolic polysomal profiles of TTP mRNA depend on catalytic activity of p38 and MK2. C) siRNA mediated knockdown of HuR (MK2+siHuR) inhibits MK2-dependent translation of TTP mRNA. D) Knockdown of HuR decreases LPS-induced TTP expression. Western blots of macrophage lysates prepared 4 h after LPS-induction.</p
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