Cardiac dysfunction and reduced FAO related mRNA expression with aging in MHC-hAR mice.

<p>13 month old mice were used in these studies. (<b>A</b>) The heart to body weight ratio was increased in MHC-hAR mice (n = 9–12). (<b>B and C</b>) Echocardiographic measurements showed increased left ventricular systolic dimension and reduced fractional shortening with age in MHC-hAR mice. (<b>D</b>) MHC-hAR transgene altered cardiac FA and glucose oxidation gene expression in mice. FS, fractional shortening; LVDs, left ventricular end-systolic dimension. Data are shown as mean ± SD. *P<0.05, ^#P<0.01, and ^§P<0.001 versus littermate controls.