Optical assessment of vascular disruption in U87-mCherry-luc tumors.

<p>Optical imaging was performed at various times before and after administration of ATO. On each occasion FLI was performed first and then <i>D</i>-luciferin was administered SC in the neck and BLI was performed over a period of 16 mins. <b>A</b>) Sequential FLI with respect to a dose of 8 mg/kg ATO administered IP, <b>B</b>) Corresponding time course of bioluminescent signal evolution in this mouse following luciferin injection at respective times, <b>C</b>) BLI signal intensity at the 10 minute time point following luciferin administration, <b>D</b>) Normalized BLI signal intensity at 10 minute time point after administration of luciferin indicating vascular shutdown following various doses of ATO.