Zebrafish and human Torsin1 family proteins are highly homologous.

<p><b>A:</b> The AlignX implementation of the ClustalW algorithm was used to align the amino acid sequences of zebrafish Torsin1a and 1b, and human TorsinA and TorsinB. The Walker A (ATP binding), Walker B (ATP hydrolysis), Sensor 1 and Sensor 2 domains are labeled. The position of the glutamic acid deletion associated with DYT1 dystonia is indicated. Identical and similar amino acids at each position of the alignment are colored as shown. <b>B:</b> Zebrafish Torsin1a is depicted schematically showing the functional domains discussed in the text. The graph below shows similarity between zebrafish Torsin1a and human TorsinA at each position of a sliding 15-amino acid window of comparison, corresponding to the schematic drawing of Torsin1 above (0 = no homology, 1 = identity). Key: ER, endoplasmic reticulum signal; HD, hydrophobic domain.