Effect of carbon monoxide postconditioning on retinal expression of caspase-3 mRNA and caspase-3 cleavage.

<p>(<b>A</b>) Fold induction of caspase-3 mRNA expression in ischemic retinal tissue compared to GAPDH in relation to the corresponding non-ischemic retinae analyzed by RT-PCR (n = 8 per group; mean±SD; * p = 0.007, 0.002, <0.001 and 0.006 I/R vs. I/R+CO at 12, 24, 48 and 72 h). (<b>B</b>) Representative Western blot images (of n = 4) analyzing the suppression of retinal cleavage of caspase-3 protein by carbon monoxide postconditioning. Densitometric analysis of n = 4 western blots (mean±SD; p = 0.042 and 0.028 I/R vs. I/R+CO at 24 and 48 h).