GBS binding to fibrinogen is mediated by Srr1.

<p>(A) GBS strains COH31 (left) and NCTC 10/84 (right) were compared with their Δ<i>srr1</i> variants (Δ<i>srr1</i>) for binding to the wells pretreated with fibronectin or fibrinogen (0.1 µM per well). (B) Inhibition of GBS binding to fibrinogen by anti-Srr1 IgG. COH31 strain was co-incubated with rabbit anti-Srr1 IgG or normal rabbit IgG, and relative binding to immobilized with fibrinogen. Values are mean ± S.D. of relative binding, normalized for WT levels of binding to fibrinogen. * = P<0.01.