Stereoselective Radical Amination of Electron-Deficient C(sp³)–H Bonds by Co(II)-Based Metalloradical Catalysis: Direct Synthesis of α‑Amino Acid Derivatives via α‑C–H Amination

The cobalt(II) complex of 3,5-Di^<i>t</i>Bu-IbuPhyrin, [Co(<b>P1</b>)], is an effective catalyst for intramolecular amination of electron-deficient C–H bonds, including those adjacent to electron-withdrawing CO₂R, C(O)NR₂, C(O)R, and CN groups, in excellent yields with high regio- and stereoselectivity. The [Co(<b>P1</b>)]-catalyzed amination system provides a direct method for the synthesis of α-amino acid derivatives from the corresponding carboxylate precursors