Functional screen of paracrine factors in co-culture of CAF with T47D cells. A.

<p>Red-green heat map representation of CAF co-culture-induced T47D cell growth in the presence or absence of neutralizing antibodies. Antibody treatment and calculation of Co-culture-induced T47D cell growth were performed as described in the legend of <b>Fig. 3</b>. Color changes from green to red as value increases. Each row depicts data for CAF from an individual patient (Pt number on left). The tumor grade is indicated on the left-hand side of Pt number. Cases are stratified into low grade (G1 and G2) and high grade (G3). Asterisk denotes neutralizing antibodies, where significant differences were detected between low-grade and high-grade cancer group. Each data point represents the mean of 3–6 replicates. <b>B.</b> Scatter plot representation of the data shown in panel “<b>A</b>”. Student t-test was applied to compare specific treatment vs. no antibody control. * P = 0.0006, ** P<0.0001.