Nanostructured Thin Film Polymer Devices for Constant-Rate Protein Delivery

Herein long-term delivery of proteins from biodegradable thin film devices is demonstrated, where a nanostructured polymer membrane controls release. Protein was sealed between two poly­(caprolactone) films, which generated the thin film devices. Protein release for 210 days was shown <i>in vitro</i>, and stable activity was established through 70 days with a model protein. These thin film devices present a promising delivery platform for biologic therapeutics, particularly for application in constrained spaces