Serum miR-155 levels in normal controls (n = 55) and breast cancer patients (n = 103).

<p>The relative expression level of miR-155 was normalized to spiked-in cel-mir-39. The line represents the median value. Statistically significant difference was determined using Mann-Whitney tests. The result revealed a higher level of miR-155 in breast cancer patients (<i>p</i><0.001) (A). Box plot of serum miR-155 expression levels across stages. The boxes indicate the 25th and 75th percentiles and the bold lines represent the median values. The relative expression levels of target miRNA were normalized to spiked-in cel-mir-39. Statistically significant differences were determined using Mann-Whitney tests or Kruskal-Wallis tests (B). Receiver operating characteristics (ROC) curve analysis for the diagnostic value of miR-155. The AUC (the areas under the ROC curve) was 0.801 (95% CI: 0.734 to 0.868) (C).