Features and functional analysis of temporal co-expression clusters of LCGs.

<p>(A) The heatmap exhibits the four co-expression clusters of the LCGs. Bright red and blue represent co-expression value as 1 and -1, respectively. In each cluster, the gene order ranked based on the consensusNMF result. The four clusters are arranged by their temporal phases and named as the dawn, the day, the dusk, and the night clusters. (B) The number of genes per phase in the four liver clusters. The radial plot displays phases (h) on the circumference and the number of genes on the radius. (C) Standard deviations of the phase-associated genes (dawn, day, dusk, and night) of the liver among different time points are shown in different color-coded boxes (purple, orange, green and blue boxes, respectively). The genomic length (D), 3′-UTR length (E) and CDS length (F) of the dawn, the day, the dusk, and the night clusters are shown in purple, orange, green, and blue boxes, respectively. The boxes depict data between the 25th and 75th percentiles with central horizontal lines and solid circles representing the median and mean values, respectively, and whiskers showing 5th and 95th percentiles. <i>P</i>-values are calculated based on the Wilcoxon rank sum test. (*), <i>P</i>-value<0.05. (***), <i>P</i>-value<0.001. NS, not significant.