Physical maps of M003-A06 of the human and chimpanzee.

<p>Top, chromosomal location of M003-A06 with its flanking genes indicated. Below the top map are the exon-intron gene organization and protein structure of M003-A06. The protein-coding sequences of the exons are in black. The positions of the non-synonymous nucleotides of the human H, C1 and C2 alleles in comparison to the chimpanzee homolog are indicated by the stars. The arrow head and the two arrows indicate the non-synonymous nucleotide substitutions that create the stop codon in the human H allele and the alternative splicing sites in the human C1 and C2 alleles, respectively. The synonymous nucleotide substitution in the chimpanzee gene is indicated by the vertical line.