Comparison of pathway fluxes as a function of productivity.

<p>The molecular flux through individual reactions was obtained from the biochemical models running at steady state. The colour of the arrows connecting the model species indicates the molecular flux from one species to the next in molecules per time unit. The left hand panel show absolute pathway fluxes for three cell lines. The right hand panel shows relative fluxes, normalised to the highest individual reaction flux observed for each cell line. The diagrams shown are for the “HL” assembly pathway. H.mRNA (heavy chain mRNA), L.mRNA (light chain mRNA), LHHL (assembled antibody), LH (half antibody species), H (heavy chain), HH (heavy chain dimer), HHL (heavy chain dimer + 1 light chain), LL (light chain dimer), L (light Chain), mAb (assembled secreted antibody).