<p>The peptide concentrations are from left to right 7.97, 2.36, 1.00, 0.51, 0.30, and 0.19 mM. The fitted size of nucleus and growth rate are 3.8 particle and respectively. The inset shows the fit to obtain the nucleus size via the halftimes according to <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002692#pcbi.1002692.e067" target="_blank">Eq. 2</a>. The logarithmic time scale tends to visually over-emphasize the differences between the global fit (red curve) and data (black curve) at short time (highest concentrations).</p
The initial concentration of monomeric amyloidogenic proteins is a crucial factor in the in vitro fo...
We present a coarse-grained computer model designed to study the growth of fibres in a synthetic sel...
<p>(A-B) Data from eight experiments (total n = 22 for Aβ 1–42) is shown. Error bars = SD. * p < 0.0...
<p>All the theoretical curves displayed with non-black colors were able to fit the simulation data v...
Quantitative prediction of the fibril growth properties of different peptides is conducted with a mo...
<p>At a mean filament length of 5 ULFs length distribution profiles simulated at various concentrati...
The question about the size of nuclei of formation of protofibrils (which constitute mature amyloid ...
<p>The blue/red particles are in the random coil state, while the orange/grey particles are in the -...
<p>In such systems, the fibers can bend to form a ring (depicted as a simulation snapshot in part B)...
<p><b>(A–D)</b> Elongation of straight fibrils in imaging buffer A. The peptide concentration was 12...
Abstract: Fibril formation of proteins and peptides is associated with a large group of major human ...
<p>At the bottom, one can see the decreasing concentration of monomers (red/yellow), dimers (green/b...
The initial concentration of monomeric amyloidogenic proteins is a crucial factor in the in vitro fo...
The growth of amyloid fibrils requires a disordered or partially unfolded protein to bind to the fib...
International audienceMany different proteins self-aggregate into insoluble fibrils growing apically...
The initial concentration of monomeric amyloidogenic proteins is a crucial factor in the in vitro fo...
We present a coarse-grained computer model designed to study the growth of fibres in a synthetic sel...
<p>(A-B) Data from eight experiments (total n = 22 for Aβ 1–42) is shown. Error bars = SD. * p < 0.0...
<p>All the theoretical curves displayed with non-black colors were able to fit the simulation data v...
Quantitative prediction of the fibril growth properties of different peptides is conducted with a mo...
<p>At a mean filament length of 5 ULFs length distribution profiles simulated at various concentrati...
The question about the size of nuclei of formation of protofibrils (which constitute mature amyloid ...
<p>The blue/red particles are in the random coil state, while the orange/grey particles are in the -...
<p>In such systems, the fibers can bend to form a ring (depicted as a simulation snapshot in part B)...
<p><b>(A–D)</b> Elongation of straight fibrils in imaging buffer A. The peptide concentration was 12...
Abstract: Fibril formation of proteins and peptides is associated with a large group of major human ...
<p>At the bottom, one can see the decreasing concentration of monomers (red/yellow), dimers (green/b...
The initial concentration of monomeric amyloidogenic proteins is a crucial factor in the in vitro fo...
The growth of amyloid fibrils requires a disordered or partially unfolded protein to bind to the fib...
International audienceMany different proteins self-aggregate into insoluble fibrils growing apically...
The initial concentration of monomeric amyloidogenic proteins is a crucial factor in the in vitro fo...
We present a coarse-grained computer model designed to study the growth of fibres in a synthetic sel...
<p>(A-B) Data from eight experiments (total n = 22 for Aβ 1–42) is shown. Error bars = SD. * p < 0.0...