Vein graft lesion showing complex morphology including plaque rupture complications.

<p><b>A</b>; Cross-section stained with a Masson trichrome staining of a vein graft in an ApoE3Leiden mouse 28 days after surgery. Coloured squares depict location of photographs B–G. L represents lumen and A; adventitia <b>B</b>; Part of the lesion showing foamcells (white arrows) and SMC’s, with a smooth muscle cell rich cap underneath an intact endothelial layer (black arrows; endothelial cells) <b>C</b>; Foamcell rich area including the start of a dissection. <b>D</b>; A small necrotic core with cholesterol clefts and foam cells can be seen with a SMC rich layer and endothelial cells on top. <b>E</b>; Calcification rich area (arrows) near the outer layer of the vessel wall. <b>F</b>; Area with extravasated erythrocytes (arrows) and neovascularization (#). <b>G</b>; Detailed photograph of dissection and extravasated erythrocytes 150 µm upstream in the lesion (arrows; erythrocytes stuck in the dissection).