mTORC1downstream signaling is inhibited and p-ERK1/2 is activated by BEZ235 at 100 nmol/L.
- Shu-Fu Lin (126854)
- Yu-Yao Huang (126858)
- Jen-Der Lin (126862)
- Ting-Chao Chou (126865)
- Chuen Hsueh (126868)
- Richard J. Wong (126870)
Publication date
October 2012
DOIAbstract
<p>p-AKT (Thr308) and p-AKT (Ser473) was increased in 8505C for more than 24 hours. p-AKT (Thr308) and p-AKT (Ser473) was decreased transiently in TT and BHP7-13. p-4E-BP1 (Thr70), p-4E-BP1 (Thr37/46) and p-S6 ribosomal protein (Ser235/236) were consistently reduced from 2 hours through over 24 hours in three cell lines. BEZ235 caused a rapid increase of p- ERK1/2 (Thr202/Tyr204) by 2 to 4 hours in three cell lines.</p
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