MAPK signalling to CITED2 enhances its co-activation function.

<p>Hep3B cells were transiently transfected with the 3xAP2-luciferase reporter, with CMV-lacZ, CITED2-expressing plasmid or the control vector and plasmids expressing MAPK1 or the control vector and with plasmids expressing a defective MAPKK1 (SV40-MAPKK1-S221A) or a constitutively active MAPKK1 (SV40-MAPKK1-S217ES221E). <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046256#s2" target="_blank">Results</a> are presented as relative luciferase units corrected for lacZ activity. The control transfection value (at the extreme left) in each case (with CMV-vector) is set at 1.