Haplotype effect of variants rs2735940 and rs2853669 on the promoter transcription activity of <i>hTERT</i> gene.

<p>The luciferase reporter plasmids containing the <i>hTERT</i> gene promoter region with haplotype T-T, T-C, C-T, or C-C (rs2735940 and rs2853669) were constructed and then transfected into Hek293S cells. (A) Without co-transfection of transcription factors Ets2 and c-Myc; (B) With co-transfection of Ets2; (C) With co-transfection of c-Myc; (D) With co-transfection of both Ets2 and c-Myc. Data shown are the means ± SD, n = 3. **<i>P</i><0.001, compared with the relative luciferase activity of the wild-type haplotype T-T.