(A) Confocal imaging of spiroligomer 3 (2 µM 3, incubated for 24 hours and then washed with PBS) in live Huh7 cells.

<p>Yellow lines represent two orthogonal sections of a z-series showing the distribution of green fluorescence in the cells. (B) Optically sectioned HepG2 cells exposed to spiroligomer <b>1</b> (0.5 µM <b>1</b>, incubated for 15 hours and then washed with PBS) by confocal microscopy. Spiroligomer <b>1</b> is localized in both cytoplasmic and nuclear compartments.