Transition pathways in the C4L-O4L model at saturating fcAMP.

<p>The weight of the pathway net probability fluxes, obtained by <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002721#pcbi.1002721.e006" target="_blank">equation (5)</a>, is given by the numbers besides the colored graphs (as fraction of unity) and, for values >0.030, also encoded by the thickness of the arrows. Fluxes from 0.002 to 0.030 are illustrated by equally thick dotted arrows. All other fluxes are only very small (<4.5×10⁻⁴) and therefore not represented by arrows. For further explanation see text. (<i>A</i>) Pathway net probability fluxes along the pathways <i>C</i>₀ to <i>O</i>₄ (red) and <i>O</i>₀ to <i>O</i>₄ (blue) after switching to 7.5 µM fcAMP. (<i>B</i>) Pathway net probability fluxes along the pathways <i>O</i>₄ to <i>C</i>₀ (red) and <i>O</i>₄ to <i>O</i>₀ (blue) after removing fcAMP.