Individual variability in EIBS development.

<p>On the first day of the experiment (habituation day, H), all mice were injected with saline solution (n = 60). Then, from days 1 to 10, mice received 10 consecutive once-daily i.p. injections of saline (n = 20) or 2 g/kg ethanol (n = 40) solution immediately followed by a 5 min-long locomotor activity recording session. Some mice exhibited EIBS (sensitized mice, n = 29) whereas others failed to sensitize (resistant mice, n = 11). At day 17 (challenge day) mice received a single injection of saline (control group) or 2 g/kg ethanol (acute, resistant and sensitized groups). * indicates an increase <i>vs</i> day 1. † indicates a significant difference between resistant and sensitized mice at the same day. # indicates significant differences between sensitized and acute mice at day 17. @ indicates significant differences between resistant and sensitized groups throughout the induction phase.