Englerin A sensitivity does not correlate with any known mutations in kidney cancer cell lines.

<p>Renal cell carcinoma cell lines from the NCI-60 cell panel and a glioblastoma cell line (SF-295) were arranged by decreasing sensitivity to the englerin A natural product as determined by Akee and colleagues. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048032#pone.0048032-Akee1" target="_blank">[11]</a> The known mutation status in the cell lines as characterized by Ikediobi and colleagues <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048032#pone.0048032-Ikediobi1" target="_blank">[44]</a> and as obtained from the Wellcome Trust Sanger Institute Cancer Genome Project web site (<a href="http://www.sanger.ac.uk/genetics/CGP" target="_blank">http://www.sanger.ac.uk/genetics/CGP</a>) are shown in red (mutated) or green (wild-type).