<p>The circles and rectangles in the network correspond to drugs and metabolic subpathways, respectively. A drug and a metabolic subpathway are connected by an edge if the corresponding drug-affected genes are statistically significantly enriched to the corresponding subpathway. Node size is proportional to the degree of the node. Nodes are colored according to 14 ATC and 11 KEGG pathway categories.</p
<p>Circular nodes denote molecular substances, square nodes denote diseases. Several high density “n...
<p>Association network between metabolites. Red edges indicate positive correlation (Spearman>0.2); ...
<p>Gene-to-metabolite networks in snapdragon petals. ESTs are represented by gray circles and metabo...
<div><p>A fundamental issue in biology and medicine is illustration of the overall drug impact which...
<p>We generated the drug–metabolic subpathway network (DRSN) based on the drug-affected genes and pa...
A fundamental issue in biology and medicine is illustration of the overall drug impact which is alwa...
<p>A: For genes that are associated with human diseases and immune pathways, larger dots correspond ...
<p>The figure indicates the relationship among the ten most influential DMETs and the top 100 prescr...
<p>(A) There were 743 metabolic subpathways when the setting k = 3. There were 302 disease–related s...
One of the challenging problems in the etiology of diseases is to explore the relationships between ...
<p>All the examples are from the DRSN (<b>A</b>) Some antibiotic drugs were linked to steroid hormon...
<p>The DT network was generated using known FDA-approved small molecule DT interactions. The size of...
<p>The large circle corresponds to disease, and the smaller circle in a different color corresponds ...
<p>Nodes represent pathways and edges represent crosstalk between pathways. Node size corresponds to...
<p>A) Drug name and number of high correlated genes mapped from the human PHEO and the murine MTT mi...
<p>Circular nodes denote molecular substances, square nodes denote diseases. Several high density “n...
<p>Association network between metabolites. Red edges indicate positive correlation (Spearman>0.2); ...
<p>Gene-to-metabolite networks in snapdragon petals. ESTs are represented by gray circles and metabo...
<div><p>A fundamental issue in biology and medicine is illustration of the overall drug impact which...
<p>We generated the drug–metabolic subpathway network (DRSN) based on the drug-affected genes and pa...
A fundamental issue in biology and medicine is illustration of the overall drug impact which is alwa...
<p>A: For genes that are associated with human diseases and immune pathways, larger dots correspond ...
<p>The figure indicates the relationship among the ten most influential DMETs and the top 100 prescr...
<p>(A) There were 743 metabolic subpathways when the setting k = 3. There were 302 disease–related s...
One of the challenging problems in the etiology of diseases is to explore the relationships between ...
<p>All the examples are from the DRSN (<b>A</b>) Some antibiotic drugs were linked to steroid hormon...
<p>The DT network was generated using known FDA-approved small molecule DT interactions. The size of...
<p>The large circle corresponds to disease, and the smaller circle in a different color corresponds ...
<p>Nodes represent pathways and edges represent crosstalk between pathways. Node size corresponds to...
<p>A) Drug name and number of high correlated genes mapped from the human PHEO and the murine MTT mi...
<p>Circular nodes denote molecular substances, square nodes denote diseases. Several high density “n...
<p>Association network between metabolites. Red edges indicate positive correlation (Spearman>0.2); ...
<p>Gene-to-metabolite networks in snapdragon petals. ESTs are represented by gray circles and metabo...