Drug–disease associations through affected metabolic subpathways.

<p>(A) There were 743 metabolic subpathways when the setting k = 3. There were 302 disease–related subpathways according to the disease–metabolic subpathways association in the DMSPN and 403 drug-affected subpathways in the DRSN. 230 subpathways were overlapped between the two sets of subpathways. (B) The association scores between each drug class and disease class. The darker color represents the higher association scores.