Binder non-binder discrimination by scoring energies for morphing approach.

<p>Best scoring results for docking of true, foreign and non-binders to apo (first row), 5 morphing intermediate receptor structures (row 2 to 6) and the bound receptor structure pdb ID 2UPJ and using flexible receptor docking (using interpolation between the 7 different receptor structures). The dotted line marks the best binding energy obtained for the non-binder molecules. The cross symbols indicate the results of flexible receptor docking and are included for comparison for each docking to a rigid protease receptor (see also legend of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048008#pone-0048008-g006" target="_blank">Figure 6</a>).