Effects of alternative genotype-phenotype mappings.

<p>(<b>A</b>) Different assumptions of genotype-phenotype mapping, showing how the production ratio parameter <i>P</i> depends on the proportion of sites that match on the relevant genome regions G_HP and G_TP. The function form is . The values of the exponential constant are: <i>h = 0.5</i> for the concave-down curve in blue, <i>h = 1</i> for the straight line in red, <i>h = 2</i> for the concave-up curve in green. The black dotted line shows the minimum <i>P</i> value required for mutant TIP to invade the system (invasion threshold, <i>P</i>_threshold). (<b>B</b>) The probability that TIP population was eliminated, under different assumptions of genotype-phenotype mapping (color-coding is same with (A)) for different lengths of the representative genome for parameter <i>P</i>. Each bar reflects the outcome of 100 runs of the multi-strain model. (<b>C</b>) A representative model realization showing the elimination of TIP. In this model, only variations in <i>P</i> are considered with parameters <i>A = 1</i> and <i>D = 0</i> fixed for all cells, and the length of representative genome is 4.