Phagocytosis is impaired in MRP14 deficient macrophages.

<p>Growth arrested, CFSE-labelled <i>K. pneumoniae</i> were incubated with peripheral blood neutrophils (A) or macrophages (B) from Wt (grey) and <i>mrp14^−/−</i> mice (white) at 4°C (n = 3–4 per mouse strain) or 37°C (n = 6–8 per mouse strain) for 20 and 60 minutes respectively after which phagocytosis was quantified (see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002987#s4" target="_blank">Materials and Methods</a>). Data are expressed as box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile and largest observation (8 mice per group at each time point). *p<0.05.