Site of neuroimmunological BBB opening in symptomatic ECM mice.

<p>Capillaries, arterioles, and PCV from PbA-infected CBA/CaJ mice before ECM (day 5), at the time of neurological signs (typically between days 6 and 7), and post ECM (day 8). The images show that leakage of Evans blue occurs only from PCV and only during, not before or after, symptomatic ECM. Neither PCV nor arterioles or capillaries from PyXL-infected mice with HP or uninfected control mice (Con) exhibit any leakage. Scale bars = 50 µm.