A murine miRNA, sno-miR-#3, derived from snoRNA Snora7a.

<p>(A) Folding structure of the snoRNA carrying a hairpin shaped structure. The miRNAs (annotated in red) on 5′ and 3′ arm form a duplex with 1-nt 3′ overhang. (B) Length distribution of the total reads mapped to the snoRNA, which peaked at 22-nt. (C) snoRNA gene annotated in Ensembl and RefSeq annotations. Snora7a resides within an intron of Rpl32. The red arrow indicates the orientation of the snoRNA gene. The conservation score by PhyloP shows how well each base pair is conserved in mammals. (D) Alignment of reads representing miRNA sequences (red) and snoRNA fragments (blue), which appeared in Dicer- and Dgrc8-knockout mice.