Anti-SAPN antibody titer, avidity index and protection in mice immunized with <i>Pf</i>CSP-SAPNs.
- Stephen A. Kaba (125098)
- Margaret E. McCoy (125100)
- Tais A. P. F. Doll (125102)
- Clara Brando (125105)
- Qin Guo (125106)
- Debleena Dasgupta (125107)
- Yongkun Yang (125108)
- Christian Mittelholzer (125109)
- Roberta Spaccapelo (125111)
- Andrea Crisanti (125113)
- Peter Burkhard (125115)
- David E. Lanar (83862)
Publication date
October 2012
DOIAbstract
<p>Analysis of sera from individual mice immunized with <i>Pf</i>CSP-SAPNs for anti-SAPN specific antibody titer, IgG concentration and avidity index vis-à-vis the protection status of each mouse. All sera used in this analysis were taken 48 wks post-3<sup>rd</sup> immunization (wk 52 of study), one day before mice were challenged. P = protected from challenge dose of transgenic sporozoites. NP = not protected from challenge dose of transgenic sporozoites.</p
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