Guanine is a major target for oxidation in DNA, with 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) as a major product. 8-oxodG is itself significantly more susceptible to oxidation than guanine, with the resulting damage consisting of more than 10 different products. This complexity has hampered efforts to understand the determinants of biologically relevant DNA oxidation chemistry. To address this problem, we have developed a high mass accuracy mass spectrometric method to quantify oxidation products arising site specifically in DNA. We applied this method to quantify the role of sequence context in defining the spectrum of damage products arising from oxidation of 8-oxodG by two oxidants: nitrosoperoxycarbonate (ONOOCO<sub>2</sub><sup>–</...
Analysis of cellular 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo) as a biomarker of oxidative DN...
Oxidative DNA damage is one of the most important and most studied mechanisms of disease. It has bee...
Oxidative DNA damage is one of the most important and most studied mechanisms of disease. It has bee...
Guanine is a major target for oxidation in DNA, with 8-oxo-7,8-dihydro- 2′-deoxyguanosine (8-oxodG) ...
Available in PMC 2013 February 20The goal of this study was to define the effect of DNA sequence on ...
The goal of this study was to define the effect of DNA sequence on the reactivity of 8-oxo-7,8-dihyd...
Oxidative damage to DNA has long been associated with aging and disease, with guanine serving as the...
ABSTRACT: Oxidative damage to DNA has many origins, including irradiation, inflammation, and oxidati...
Oxidative damage to DNA has many origins, including irradiation, inflammation, and oxidative stress,...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, February 20...
Despite a variety of antioxidant defenses, cellular production of oxidants such as reactive oxygen s...
Despite a variety of antioxidant defenses, cellular production of oxidants such as reactive oxygen s...
DNA oxidation by reactive oxygen species is nonrandom, potentially leading to accumulation of nucleo...
Guanine is the most easily oxidized among the four DNA bases, and some guanine-rich sequences can fo...
Free radical mechanism of a cell damage is one of the universal non-specific pathogenic pathways in ...
Analysis of cellular 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo) as a biomarker of oxidative DN...
Oxidative DNA damage is one of the most important and most studied mechanisms of disease. It has bee...
Oxidative DNA damage is one of the most important and most studied mechanisms of disease. It has bee...
Guanine is a major target for oxidation in DNA, with 8-oxo-7,8-dihydro- 2′-deoxyguanosine (8-oxodG) ...
Available in PMC 2013 February 20The goal of this study was to define the effect of DNA sequence on ...
The goal of this study was to define the effect of DNA sequence on the reactivity of 8-oxo-7,8-dihyd...
Oxidative damage to DNA has long been associated with aging and disease, with guanine serving as the...
ABSTRACT: Oxidative damage to DNA has many origins, including irradiation, inflammation, and oxidati...
Oxidative damage to DNA has many origins, including irradiation, inflammation, and oxidative stress,...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, February 20...
Despite a variety of antioxidant defenses, cellular production of oxidants such as reactive oxygen s...
Despite a variety of antioxidant defenses, cellular production of oxidants such as reactive oxygen s...
DNA oxidation by reactive oxygen species is nonrandom, potentially leading to accumulation of nucleo...
Guanine is the most easily oxidized among the four DNA bases, and some guanine-rich sequences can fo...
Free radical mechanism of a cell damage is one of the universal non-specific pathogenic pathways in ...
Analysis of cellular 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxo-dGuo) as a biomarker of oxidative DN...
Oxidative DNA damage is one of the most important and most studied mechanisms of disease. It has bee...
Oxidative DNA damage is one of the most important and most studied mechanisms of disease. It has bee...