<p>ASD for each locus compared with mutation rates for each locus, using three published studies. A) Burgarella rates, 32 loci. Loci identified in bold face (e.g., DYS448) fall within the 95% mean confidence interval for the locus set compared. B) Ballantyne rates, 32 loci. C) YHRD, 15 loci, YHRD rates. D) Burgarella rates, 24 loci, with loci that have 0.001 removed from the calculation. Data set compared is from the “British Isles DNA Project,” n = 245, 32 locus haplotypes and subsets of the same data set (24 locus reduced set and 15 locus set corresponding to the YHRD ssSTR loci.).</p
<p>A total of 2923 genomic loci spaced 1Mb from each other were defined, and the average estimated l...
<p>Characteristics of causal loci at which KBAC (the method with highest mean power at nominal level...
<p>Power estimates for BOMP, VT, SKAT, KBAC (KBAC1P = minor allele frequency defined as , KBAC5P = m...
<p>A) Burgarella mutation rates, 32 loci, best to worst order. B) Ballantyne mutation rates, 32 loci...
<p>For comparison, Ballantyne et al.<sup>11</sup> estimates are reported (BALL). NMUT: number of obs...
<p>Box plots indicate the posterior predictive distributions for each locus (1,000 replicates; horiz...
<p>Dotted vertical lines represent 95% confidence intervals (when available). For comparison, estima...
<p>Heritability (y-axis) per chromosome is plotted against chromosome length (x-axis). The red line ...
<p>(A) The relationship between the number of ASD risk genes () and the average relative risk (). s...
Panels (a)—(d) show results from simulations using 25, 50, 75 and 100 loci respectively. As describe...
<p>Forest plots showing the odds ratios (OR) and confidence intervals (CI) of the <i>IL33</i> rs2075...
<p>Power estimates for BOMP, VT, SKAT, KBAC (KBAC1P = minor allele frequency defined as , KBAC5P = m...
<p>Testing Accuracy for different combinations: single locus, 63.7 %; two locus, 65.1%; three locus,...
<p>For each comparison, 75 individuals were subsampled with replacement from each sub-epoch and 1,00...
<p>Note gene is the best proximal candidate or closest gene to the locus and may not be the true pat...
<p>A total of 2923 genomic loci spaced 1Mb from each other were defined, and the average estimated l...
<p>Characteristics of causal loci at which KBAC (the method with highest mean power at nominal level...
<p>Power estimates for BOMP, VT, SKAT, KBAC (KBAC1P = minor allele frequency defined as , KBAC5P = m...
<p>A) Burgarella mutation rates, 32 loci, best to worst order. B) Ballantyne mutation rates, 32 loci...
<p>For comparison, Ballantyne et al.<sup>11</sup> estimates are reported (BALL). NMUT: number of obs...
<p>Box plots indicate the posterior predictive distributions for each locus (1,000 replicates; horiz...
<p>Dotted vertical lines represent 95% confidence intervals (when available). For comparison, estima...
<p>Heritability (y-axis) per chromosome is plotted against chromosome length (x-axis). The red line ...
<p>(A) The relationship between the number of ASD risk genes () and the average relative risk (). s...
Panels (a)—(d) show results from simulations using 25, 50, 75 and 100 loci respectively. As describe...
<p>Forest plots showing the odds ratios (OR) and confidence intervals (CI) of the <i>IL33</i> rs2075...
<p>Power estimates for BOMP, VT, SKAT, KBAC (KBAC1P = minor allele frequency defined as , KBAC5P = m...
<p>Testing Accuracy for different combinations: single locus, 63.7 %; two locus, 65.1%; three locus,...
<p>For each comparison, 75 individuals were subsampled with replacement from each sub-epoch and 1,00...
<p>Note gene is the best proximal candidate or closest gene to the locus and may not be the true pat...
<p>A total of 2923 genomic loci spaced 1Mb from each other were defined, and the average estimated l...
<p>Characteristics of causal loci at which KBAC (the method with highest mean power at nominal level...
<p>Power estimates for BOMP, VT, SKAT, KBAC (KBAC1P = minor allele frequency defined as , KBAC5P = m...