<p>Abbreviations are: <i>n</i>, number of cells per group; <i>k</i>, slope factor of voltage dependence of (in)activation (mV) and V<sub>1/2</sub>, voltage of half-maximal (in)activation (mV). Statistically significant results were determined using one-way analysis of variance (ANOVA) with Bonferroni's post hoc tests. <sup>*</sup>, P<0.05; <sup>**</sup>, P<0.01 (<i>vs</i> WT/(-) + β<sub>1</sub>); <sup>†</sup>, P<0.05; <sup>††</sup>, P<0.01 (<i>vs</i> WT/R1432G + β<sub>1</sub>).</p
<p>V<sub>1/2</sub>, midpoint of activation and inactivation; k, slope factor; n, number of cells. Va...
<p>(A–D) Activation curves of wild type and I136V, I848T, V1316A mutant channels at 25°C (solid dots...
<p>Numbers tested are in parentheses.</p><p>*p<0.05 vs WT.</p><p>Electrophysiological parameters for...
<p>V<sub>50</sub> (half activation voltage) and z (equivalent gating charge) were derived from fitti...
<p>V<sub>50</sub> (half activation voltage) and z (equivalent gating charge) were derived from fitti...
<p>(A) Representative current traces recorded from a HEK-Na<sub>v</sub>1.6 cell using the indicated ...
<p>(Aa) Exemplar gating current at reversal potential (∼65 mV) for WT channels expressed with β2a. (...
<p>V<sub>1/2</sub>, voltage of half-maximal (in)activation; k, slope factor of voltage- dependence o...
<p>The values of V<sub>50</sub> and k were calculated for each cell, then averaged. R values determi...
<p><b>V0.5<sub>act</sub>,</b> Voltage of half-maximal activation; <b>V0.5<sub>inact</sub>,</b> half-...
<p><i>Aa</i>, Schematic of the P/-8 voltage protocol. <i>Ab</i>, Representative current at full scal...
<p>(A) Representative current traces elicited by 20 ms depolarizing pulses from -80 mV to the indica...
<p><b>(A)</b> Representative WT and C479T activation currents elicited by the protocol in the inset....
<p><b>A.</b> IV curves of Na<sub>v</sub>1.5 currents recorded from HEK293T cells transfected with WT...
<p>act = activation, inact = inactivation, *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 as com...
<p>V<sub>1/2</sub>, midpoint of activation and inactivation; k, slope factor; n, number of cells. Va...
<p>(A–D) Activation curves of wild type and I136V, I848T, V1316A mutant channels at 25°C (solid dots...
<p>Numbers tested are in parentheses.</p><p>*p<0.05 vs WT.</p><p>Electrophysiological parameters for...
<p>V<sub>50</sub> (half activation voltage) and z (equivalent gating charge) were derived from fitti...
<p>V<sub>50</sub> (half activation voltage) and z (equivalent gating charge) were derived from fitti...
<p>(A) Representative current traces recorded from a HEK-Na<sub>v</sub>1.6 cell using the indicated ...
<p>(Aa) Exemplar gating current at reversal potential (∼65 mV) for WT channels expressed with β2a. (...
<p>V<sub>1/2</sub>, voltage of half-maximal (in)activation; k, slope factor of voltage- dependence o...
<p>The values of V<sub>50</sub> and k were calculated for each cell, then averaged. R values determi...
<p><b>V0.5<sub>act</sub>,</b> Voltage of half-maximal activation; <b>V0.5<sub>inact</sub>,</b> half-...
<p><i>Aa</i>, Schematic of the P/-8 voltage protocol. <i>Ab</i>, Representative current at full scal...
<p>(A) Representative current traces elicited by 20 ms depolarizing pulses from -80 mV to the indica...
<p><b>(A)</b> Representative WT and C479T activation currents elicited by the protocol in the inset....
<p><b>A.</b> IV curves of Na<sub>v</sub>1.5 currents recorded from HEK293T cells transfected with WT...
<p>act = activation, inact = inactivation, *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 as com...
<p>V<sub>1/2</sub>, midpoint of activation and inactivation; k, slope factor; n, number of cells. Va...
<p>(A–D) Activation curves of wild type and I136V, I848T, V1316A mutant channels at 25°C (solid dots...
<p>Numbers tested are in parentheses.</p><p>*p<0.05 vs WT.</p><p>Electrophysiological parameters for...