Sensitivity of MiMBl towards the use of alternative reference flux distributions.

<p><b>a</b>) The histogram shows the distribution of variability in the predicted growth of single gene knockout mutants while using 500 different FBA alternative optima as reference flux distributions. <b>b</b>) Case study of <i>YLR377C</i> knockout simulations using different reference flux distributions as input. The predicted growth varies between 50–100% of that of the wild-type.