Azepane Quaternary Amino Acids As Effective Inducers of 310 Helix Conformations

Entry to new conformationally constrained amino acids. First synthesis of 3-unsubstituted 4-alkyl-4-carboxy-2-azetidinone derivatives via an intramolecular Nα-Cα-cyclization strategy

Gerona-Navarro, Guillermo
Bonache de Marcos, María Ángeles
Herranz, Rosario
García-López, M. Teresa
González-Muñiz, Rosario

September 2023

A systematic study on the base-assisted intramolecular alkylation of N-benzyl-N-chloroacetyl amino a...

Synthesis and Solid State Conformation of Tetrapeptide Amides Containing two Aib and two (Me)Phe Residues – Use of Enantiomerically Pure 2-Benzyl-2-methyl-2H-azirin-3-amines as (Me)Phe-Synthons

Bucher, Christoph
Linden, Anthony
Heimgartner, Heinz

January 2020

A series of tetrapeptide amides containing two aminoisobutyric acids (Aib) and two -methylphenylalan...

A chirally stable, atropoisomeric, C-alpha-tetrasubstituted alpha-amino acid: incorporation into model peptides and conformational preference

FORMAGGIO, FERNANDO
PEGGION, CRISTINA
TONIOLO, CLAUDIO
M. CRISMA
L. TCHERTANOV
J. GUILHEM
J. P. MAZALEYRAT
Y. GOUBARD
A. GAUCHER
M. WAKSELMAN

January 2001

A variety of model peptides, including four complete homologous series, to the pentamer level, chara...

Azepane Quaternary Amino Acids As Effective Inducers of 310 Helix Conformations

Diego Núñez-Villanueva (2028769)
Lourdes Infantes (105990)
M. Teresa García-López (1810822)
Rosario González-Muñiz (1810816)
Mercedes Martín-Martínez (1810828)

November 2012

A simple method for the synthesis of an azepane quaternary amino acid in enantiopure form is describ...

β-TurnInductionby a DiastereopureAzepane-DerivedQuaternaryAminoAcid

Núñez-Villanueva, Diego
Plata-Ruiz, Adrián
Romero-Muñiz, Ignacio
Martín-Pérez, Ignacio
Infantes, Lourdes
González-Muñiz, Rosario
Martín-Martínez, Mercedes

September 2023

β-Turns are one of the most common secondary structures found in proteins. In the interest of devel...

Synthesis of Enantiopure 7-Substituted Azepane-2-Carboxylic Acids as Templates for Conformationally Constrained Peptidomimetics

Cini Elena
Menchi Gloria
Taddei Maurizio
BIFULCO, Giuseppe
RODRIQUEZ, Manuela

January 2012

The introduction of a cyclic amino acid in a peptide is one of the best methods to rigidify a strand...

Synthesis of Enantiopure 7-Substituted Azepane-2-carboxylic Acids as Templates for Conformationally Constrained Peptidomimetics

CINI, ELENA
TADDEI, MAURIZIO
G. Bifulco
G. Menchi
M. Rodriquez

January 2012

The introduction of a cyclic amino acid in a peptide is one of the best methods to rigidify a strand...

Ahead of the curve : helical behaviour of 1H-azepine-4-amino-4-carboxylic acid, a new a, a-disubstituted ornithine analogue

S. Pellegrino
A. Contini
M.L. Gelmi

August 2012

Helical motifs are key structural elements in many biological functions involving protein-protein in...

Introducing sequential aza--amino acids units induces repeated β--turns and helical conformations in peptides

Tonali, Nicolo
Correia, Isabelle
Lesma, Jacopo
Bernadat, Guillaume
Ongeri, Sandrine
Lequin, Olivier

May 2020

International audienceA major current issue in medicinal chemistry is the design of small peptide an...

Synthesis of conformationally restricted amino acids and their use in the preparation of biologically active peptides and peptidomimetics

Cattaneo, Cristian

May 2010

A very efficiently synthetic strategy was developed aiming to obtain a series of amino acids contain...

DIFFERENT APPROACHES FOR THE PREPARATION OF PEPTIDES WITH STABILIZED PREDICTABLE SECONDARY STRUCTURE

A. Gori

February 2012

Considering the importance of structural patterns in regulating protein-protein interactions (PPIs),...

Design, synthesis, conformational analysis and application of azabicycloalkane amino acids as constrained dipeptide mimics

L. Belvisi
L. Colombo
L. Manzoni
D. Potenza
C. Scolastico

January 2004

In the field of peptidomimetics, major efforts have been focused on the design and synthesis of conf...

Design, Synthesis, Conformational Analysis and Application of Azabicyclo-alkane Amino Acids as Constrained Dipeptide Mimics

BELVISI L
MANZONI L.
POTENZA D.
SCOLASTICO C.
COLOMBO, LINO

January 2004

In the field of peptidomimetics, major efforts have been focused on the design and synthesis of conf...

Aza-Amino Acids Disrupt β-Sheet Secondary Structures

Michael A. McMechen
Evan L. Willis
Preston C. Gourville
Caroline Proulx

May 2019

Cα to N substitution in aza-amino acids imposes local conformational constraints, changes in hy...

Chiral α-aminoxy acid/achiral cyclopropane α-aminoxy acid unit as a building block for constructing the α N-O helix

Chen, MQ
Weng, LH
Chang, XW
Zhang, DW
Jiang, ZF
Song, KS
Zhang, YH
Zhu, NY
Yang, D

January 2010

(Figure Presented) The monomer 1 derived from achiral 1-(aminoxy) cyclopropanecarboxylic acid (OAcc)...

Entry to new conformationally constrained amino acids. First synthesis of 3-unsubstituted 4-alkyl-4-carboxy-2-azetidinone derivatives via an intramolecular Nα-Cα-cyclization strategy

Gerona-Navarro, Guillermo
Bonache de Marcos, María Ángeles
Herranz, Rosario
García-López, M. Teresa
González-Muñiz, Rosario

September 2023

A systematic study on the base-assisted intramolecular alkylation of N-benzyl-N-chloroacetyl amino a...

Synthesis and Solid State Conformation of Tetrapeptide Amides Containing two Aib and two (Me)Phe Residues – Use of Enantiomerically Pure 2-Benzyl-2-methyl-2H-azirin-3-amines as (Me)Phe-Synthons

Bucher, Christoph
Linden, Anthony
Heimgartner, Heinz

January 2020

A series of tetrapeptide amides containing two aminoisobutyric acids (Aib) and two -methylphenylalan...

A chirally stable, atropoisomeric, C-alpha-tetrasubstituted alpha-amino acid: incorporation into model peptides and conformational preference

FORMAGGIO, FERNANDO
PEGGION, CRISTINA
TONIOLO, CLAUDIO
M. CRISMA
L. TCHERTANOV
J. GUILHEM
J. P. MAZALEYRAT
Y. GOUBARD
A. GAUCHER
M. WAKSELMAN

January 2001

A variety of model peptides, including four complete homologous series, to the pentamer level, chara...

Azepane Quaternary Amino Acids As Effective Inducers of 310 Helix Conformations

Diego Núñez-Villanueva (2028769)
Lourdes Infantes (105990)
M. Teresa García-López (1810822)
Rosario González-Muñiz (1810816)
Mercedes Martín-Martínez (1810828)

November 2012

A simple method for the synthesis of an azepane quaternary amino acid in enantiopure form is describ...

β-TurnInductionby a DiastereopureAzepane-DerivedQuaternaryAminoAcid

Núñez-Villanueva, Diego
Plata-Ruiz, Adrián
Romero-Muñiz, Ignacio
Martín-Pérez, Ignacio
Infantes, Lourdes
González-Muñiz, Rosario
Martín-Martínez, Mercedes

September 2023

β-Turns are one of the most common secondary structures found in proteins. In the interest of devel...

Synthesis of Enantiopure 7-Substituted Azepane-2-Carboxylic Acids as Templates for Conformationally Constrained Peptidomimetics

Cini Elena
Menchi Gloria
Taddei Maurizio
BIFULCO, Giuseppe
RODRIQUEZ, Manuela

January 2012

The introduction of a cyclic amino acid in a peptide is one of the best methods to rigidify a strand...

Synthesis of Enantiopure 7-Substituted Azepane-2-carboxylic Acids as Templates for Conformationally Constrained Peptidomimetics

CINI, ELENA
TADDEI, MAURIZIO
G. Bifulco
G. Menchi
M. Rodriquez

January 2012

The introduction of a cyclic amino acid in a peptide is one of the best methods to rigidify a strand...

Ahead of the curve : helical behaviour of 1H-azepine-4-amino-4-carboxylic acid, a new a, a-disubstituted ornithine analogue

S. Pellegrino
A. Contini
M.L. Gelmi

August 2012

Helical motifs are key structural elements in many biological functions involving protein-protein in...

Introducing sequential aza--amino acids units induces repeated β--turns and helical conformations in peptides

Tonali, Nicolo
Correia, Isabelle
Lesma, Jacopo
Bernadat, Guillaume
Ongeri, Sandrine
Lequin, Olivier

May 2020

International audienceA major current issue in medicinal chemistry is the design of small peptide an...

Synthesis of conformationally restricted amino acids and their use in the preparation of biologically active peptides and peptidomimetics

Cattaneo, Cristian

May 2010

A very efficiently synthetic strategy was developed aiming to obtain a series of amino acids contain...

DIFFERENT APPROACHES FOR THE PREPARATION OF PEPTIDES WITH STABILIZED PREDICTABLE SECONDARY STRUCTURE

A. Gori

February 2012

Considering the importance of structural patterns in regulating protein-protein interactions (PPIs),...

Design, synthesis, conformational analysis and application of azabicycloalkane amino acids as constrained dipeptide mimics

L. Belvisi
L. Colombo
L. Manzoni
D. Potenza
C. Scolastico

January 2004

In the field of peptidomimetics, major efforts have been focused on the design and synthesis of conf...

Design, Synthesis, Conformational Analysis and Application of Azabicyclo-alkane Amino Acids as Constrained Dipeptide Mimics

BELVISI L
MANZONI L.
POTENZA D.
SCOLASTICO C.
COLOMBO, LINO

January 2004

In the field of peptidomimetics, major efforts have been focused on the design and synthesis of conf...

Aza-Amino Acids Disrupt β-Sheet Secondary Structures

Michael A. McMechen
Evan L. Willis
Preston C. Gourville
Caroline Proulx

May 2019

Cα to N substitution in aza-amino acids imposes local conformational constraints, changes in hy...

Chiral α-aminoxy acid/achiral cyclopropane α-aminoxy acid unit as a building block for constructing the α N-O helix

Chen, MQ
Weng, LH
Chang, XW
Zhang, DW
Jiang, ZF
Song, KS
Zhang, YH
Zhu, NY
Yang, D

January 2010

(Figure Presented) The monomer 1 derived from achiral 1-(aminoxy) cyclopropanecarboxylic acid (OAcc)...

Entry to new conformationally constrained amino acids. First synthesis of 3-unsubstituted 4-alkyl-4-carboxy-2-azetidinone derivatives via an intramolecular Nα-Cα-cyclization strategy

Gerona-Navarro, Guillermo
Bonache de Marcos, María Ángeles
Herranz, Rosario
García-López, M. Teresa
González-Muñiz, Rosario

September 2023

A systematic study on the base-assisted intramolecular alkylation of N-benzyl-N-chloroacetyl amino a...

Synthesis and Solid State Conformation of Tetrapeptide Amides Containing two Aib and two (Me)Phe Residues – Use of Enantiomerically Pure 2-Benzyl-2-methyl-2H-azirin-3-amines as (Me)Phe-Synthons

Bucher, Christoph
Linden, Anthony
Heimgartner, Heinz

January 2020

A series of tetrapeptide amides containing two aminoisobutyric acids (Aib) and two -methylphenylalan...

A chirally stable, atropoisomeric, C-alpha-tetrasubstituted alpha-amino acid: incorporation into model peptides and conformational preference

FORMAGGIO, FERNANDO
PEGGION, CRISTINA
TONIOLO, CLAUDIO
M. CRISMA
L. TCHERTANOV
J. GUILHEM
J. P. MAZALEYRAT
Y. GOUBARD
A. GAUCHER
M. WAKSELMAN

January 2001

A variety of model peptides, including four complete homologous series, to the pentamer level, chara...

Azepane Quaternary Amino Acids As Effective Inducers of 3<sub>10</sub> Helix Conformations

Abstract

Extracted data

Azepane Quaternary Amino Acids As Effective Inducers of 3<sub>10</sub> Helix Conformations

Abstract

Extracted data

Related items

Related items