Superimposition of the representative conformations of wild type hIAPP_1–25 and the S20G mutant with the NMR structure.

<p>The NMR structure of hIAPP_1–37 (+3) (PDB ID: 2L86, model 1) is in yellow <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047150#pone.0047150-Nanga1" target="_blank">[12]</a>. The side chains of the NMR structure are shown using the stick model. The representative structure of the wild type hIAPP_1–25 is in cyan. The representative structures of S20G mutant are in magenta with the interhelical angle ≅40° and green with the interhelical angle ≅90° (L-shaped motif), respectively.