Summary data showing dose-dependent effects of 1-month HCT 1026 treatment on functional muscle ischemia.

<p>Graded doses of NE (NE 1, NE 2) evoked decreases in femoral vascular conductance in the resting hindlimbs that were similar among the three groups of mice. These vasoconstrictor responses were attenuated only in the contracting hindlimbs of mice fed the 300 ppm HCT 1026 diet. Numbers above the bars are NE doses in ng. AUC, area under the curve in arbitrary units; Contr., contraction. For each group, n = 12. *<i>P</i><0.05 vs. corresponding rest.