Location of B cell epitopes used in this study in the HA structure.

<p>(<b>A</b>) Schematic representation of predicted B cell epitopes used in this study. Red, hH5N1 HA58; Green, hH5N1 HA113; Yellow, hH5N1 HA175; Orange, hH5N1 HA233. (<b>B</b>) Location of receptor-binding site. Red, 130-loop; Green, 190-helix; Yellow, 220-loop. (<b>C</b>) Schematic representation of previously reported B cell epitopes. Red, LAH; Green, H5-F10 and CR6261; Yellow, H5-1C9; Cyan, H5-1B12. The image of HA structure of the A/Duck/Singapore/3/1997 strain was created with the use of PyMOL (<a href="http://www.pymol.org" target="_blank">www.pymol.org</a>) and the HA structure was obtained from the Protein Data Bank (PDB: 1JSM).