<p>Overall selectivity represents the IC<sub>50</sub> for a derivative in normal human fibroblasts divided by the value obtained in HL60 human leukemic cells. Bars represent mean±s.d. (n = 3); *, <i>p</i><0.05 compared to GDA.</p
<p>(A) Targeted inhibitors from the CCLE database. (B) Targeted inhibitors from the Sanger COSMIC da...
<p>The zymograms were analysed using spot –denso method in Alpha Ease software and data was represen...
<p>A. The structures of B02, doxorubicin, etoposide, topotecan and cisplatin. B. Survival of MDA-MB-...
<p>IDB selectivity is defined as the IC<sub>50</sub> in MD-MB-231 cells treated with scrambled shRNA...
<p>Mitoxantrone and daunorubicin are weakly basic with pKa values near 8 and have significant IDB se...
<p>For each drug, and each cell line, the GI50 is shown as a bar on a logarithmic scale relative to ...
<p>Selectivity index of the DESs for cancer cells compared with human oral keratinocyte cell line (O...
Each bar indicates the t-value calculated using the Welch test. The bars are coloured based on the l...
<p>(A) Chemical structures of anti-RMS hits. (B) IC<sub>50</sub> values of the compounds in RD and N...
A P-glycoprotein (P-gp) IC50 working group was established with 23 participating pharmaceutical and ...
<p>All concentrations are in nM and the result of a titration series with 7 drug concentrations each...
<p>A comparison was conducted using the screening approach proposed in this study (blue bars; PDB ID...
<p>TS: Treated Scenario; NS: Normal Scenario; PC: Pancreatic Cancer Scenario. The green arrow heads ...
<p><b>A</b>. Average drug response of the JIMT1 cells in different cell culture models. The average ...
<p>Each circle represents a marketed kinase inhibitor and its targeted cell growth inhibition. A: Ce...
<p>(A) Targeted inhibitors from the CCLE database. (B) Targeted inhibitors from the Sanger COSMIC da...
<p>The zymograms were analysed using spot –denso method in Alpha Ease software and data was represen...
<p>A. The structures of B02, doxorubicin, etoposide, topotecan and cisplatin. B. Survival of MDA-MB-...
<p>IDB selectivity is defined as the IC<sub>50</sub> in MD-MB-231 cells treated with scrambled shRNA...
<p>Mitoxantrone and daunorubicin are weakly basic with pKa values near 8 and have significant IDB se...
<p>For each drug, and each cell line, the GI50 is shown as a bar on a logarithmic scale relative to ...
<p>Selectivity index of the DESs for cancer cells compared with human oral keratinocyte cell line (O...
Each bar indicates the t-value calculated using the Welch test. The bars are coloured based on the l...
<p>(A) Chemical structures of anti-RMS hits. (B) IC<sub>50</sub> values of the compounds in RD and N...
A P-glycoprotein (P-gp) IC50 working group was established with 23 participating pharmaceutical and ...
<p>All concentrations are in nM and the result of a titration series with 7 drug concentrations each...
<p>A comparison was conducted using the screening approach proposed in this study (blue bars; PDB ID...
<p>TS: Treated Scenario; NS: Normal Scenario; PC: Pancreatic Cancer Scenario. The green arrow heads ...
<p><b>A</b>. Average drug response of the JIMT1 cells in different cell culture models. The average ...
<p>Each circle represents a marketed kinase inhibitor and its targeted cell growth inhibition. A: Ce...
<p>(A) Targeted inhibitors from the CCLE database. (B) Targeted inhibitors from the Sanger COSMIC da...
<p>The zymograms were analysed using spot –denso method in Alpha Ease software and data was represen...
<p>A. The structures of B02, doxorubicin, etoposide, topotecan and cisplatin. B. Survival of MDA-MB-...
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