Spermine attenuates the inhibition of transcription by actinomycin D in vitro.

<p>(<b>A</b>) The effect of ACTD on T7 RNA polymerase activity in the presence of various concentrations of spermine (SPM). (<b>B</b>) Quantification of the percentage of RNA polymerase activity relative to the control treated with or without ACTD in the presence of various concentrations of spermine (SPM) (0, 0.1, and 0.2 mM). The data represent the mean values ±SDs from three separate experiments.