Bisulfite sequencing analysis of the <i>Actn1</i> DMR in mouse, rat and human tissues.

<p>Panel A shows bisulfite sequencing results from clones isolated from rat liver, mouse liver, and human hepatocytes. Each horizontal line represents a unique clone. Red and blue lines represent maternal and paternal parent-of-origin, respectively, based on five strain-specific variants. Open circles are unmethylated CpGs, while closed circles are methylated CpGs. Green and yellow circles shown in human hepatocyte clones represent variant rs11557769 and distinguish parental alleles, although parent-of-origin is unknown. Orthologous CpGs are connected by dotted lines (in relation to mouse). Panel B shows bisulfite sequencing results from clones isolated from rat right brain hemisphere (top) and mouse right brain hemispheres (bottom).