2D-DIGE analysis and identification of selected CSF proteins.

<p>Abbreviations: PD = Parkinson’ disease, PDD = Parkinson’s dementia, CON = control persons, pI = isoelectric point of the proteins, PMF = peptide mass fingerprint, MS = mass spectrometry.</p><p>a) Mascot protein score obtained for the peptide mass fingerprint (PMF). The significance threshold was 56.</p><p>b) Mascot MS/MS ion scores obtained for the individual peptides sequenced. The significance threshold was 17–29 depending on how many peptides fell within the mass tolerance window about the precursor mass. Only the top ranking peptides matching a query for the first time (“bold red hits”) are reported.