Micro- and macroenvironment of primary and xenograft tumours.

<p>Shown here are H&E stains of primary (A) and xenograft (B) tissue slices. A. Smooth muscle tissue of the duodenum was infiltrated by tumour cells of the primary tumour. B. Invasive front of xenograft tumours with areas of infiltrative tumour expansion into the adjacent normal pancreas tissue (arrow heads). C. One out of three NSG mice developed metastasis during initial experiments when 1 Mio cells were injected orthotopically (arrow heads).