Org 214007-0 has a relatively lower impact on induction than on respression of genes.
- Marie-José C. van Lierop (120014)
- Wynand Alkema (120016)
- Anke J. Laskewitz (120017)
- Rein Dijkema (120020)
- Hans M. van der Maaden (120022)
- Martin J. Smit (120024)
- Ralf Plate (120027)
- Paolo G. M. Conti (120030)
- Christan G. J. M. Jans (120032)
- C. Marco Timmers (120034)
- Constant A. A. van Boeckel (120036)
- Scott J. Lusher (120038)
- Ross McGuire (120040)
- Rene C. van Schaik (120043)
- Jacob de Vlieg (120047)
- Ruben L. Smeets (120052)
- Claudia L. Hofstra (120057)
- Annemieke M. H. Boots (120063)
- Marcel van Duin (120068)
- Benno A. Ingelse (120071)
- Willem G. E. J. Schoonen (120077)
- Aldo Grefhorst (120082)
- Theo H. van Dijk (120087)
- Folkert Kuipers (120092)
- Wim H. A. Dokter (120097)
Publication date
November 2012
DOIAbstract
<p>Fold changes for the top 25 genes either induced (A) or repressed (B) by 1 μM prednisolone and 1 μM Org 214007-0 in THP-1 cells. NB. Scales are in 2log. Example of an induced gene, FK506 binding protein 51 (FKBP51) (C) and a repressed gene, interleukin 6 (IL-6) (D) in comparison to the vehicle control under either non-stimulated or stimulated (IFNγ/TNFα) condition. Fold changes for the top 25 genes either induced (E) or repressed (F) by 1.5 mg/kg prednisolone and 0.3 mg/kg Org 214007-0 in muscle tissue from arthritic mice. NB. Scales are in 2log. Example of an induced gene (Per-2) (G) and a repressed gene (Ccl8) (H) in comparison to vehicle treated arthritic mice and vehicle treated healthy mice.</p
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