Plasma bilirubin and (un)conjugated bile acid levels in patients on the day of diagnosis of severe sepsis.

<p>(A) The plot depicts median log₂ fold changes of bilirubin (Bili), and unconjugated as well as glycine- and taurine-conjugated bile acid quantities in plasma of severely septic patients (<i>n</i> = 48) fulfilling American College of Chest Physicians/Society of Critical Care Medicine consensus criteria compared to non-septic controls (<i>n</i> = 20) (*<i>p</i><0.05 compared to controls). (B) Receiver operating characteristics of bilirubin, CDCA, TDCA, or the combined performance of CDCA+TDCA in predicting 28-d mortality. DCA, deoxycholic acid; GDCA, glycodeoxycholic acid; GCDCA, glycochenodeoxycholic acid; GLCA, glycolithocholic acid; GLCAS, glycolithocholic acid sulphate; GUDCA, glycoursodeoxycholic acid; TCDCA, taurochenodeoxycholic acid; TLCA, taurolithocholic acid; TLCAS, taurolithocholic acid sulphate; TUDCA, tauroursodeoxycholic acid; UDCA, ursodeoxycholic acid.