MutPred pathogenicity scores of mtDNA mutations in ageing, populations, disease, and all possible mtDNA mutations.

<p>A: The distribution of pathogenicity scores in ageing, populations, disease and all possible mutations. Results of Wilcoxon rank sum analysis are shown. With six tests, the threshold for significance is 0.05/6 = 0.008, ** = p<0.0017, *** = p<0.00017. B: The distribution of pathogenicity scores including synonymous mtDNA mutations which were assigned a pathogenicity score of 0, in ageing, population and disease. Results of Wilcoxon rank sum analysis are shown. With three tests the threshold for significance is 0.05/3 = 0.017, ** = p<0.003, *** = p<0.0003. C: The distribution of pathogenicity scores in sporadic and inherited disease-causing mtDNA mutations. Results of Wilcoxon rank sum test are shown,* p<0.05.