Epithelial Coculture Mirrors In Vivo Cytokine Response.

<p>A) Cervicovaginal lavage samples from BV-negative (n = 5) or BV-positive (n = 13) women were analyzed by multiplex cytokine bead array. Fold expression for each cytokine was calculated relative to the average value of the BV-negative samples. One (p<0.05) or two (p<0.01) asterisks indicate a significant increase in cytokine concentration for the BV-positive samples over the BV-negative samples. B-D) Cytokine induction in each epithelial line B) End1, C) Ect1, and D) VK2 in response to <i>L. johnsonii</i> (average MOI = 33) and <i>A. vaginae</i> (average MOI = 13) normalized to their paired mock-inoculated conditions. One (p<0.05), two (p<0.01), or three (p<0.001) asterisks indicate a significant increase in cytokine concentration for the <i>A. vaginae</i>-inoculated conditions over the <i>L. johnsonii</i>-inoculated conditions.