<p>This graph represents the longitudinal evolution of the motor score of the treated dogs (green, individual symbols provided in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048478#pone-0048478-t001" target="_blank">table 1</a>), in comparison with the range (pink area) of values (dark red curves = min and max) obtained in a population of 24 untreated GRMD dogs, during the treatment period (2 to 9 months). Two features are uncommon and therefore noticeable: firstly the break in the curve of “Clim” [×] and “Clappy” [], and secondly the unusually low values of the motor scores obtained in the 5 other treated dogs. The motor score were significantly improved in the treated dogs between 5 and 9 months.</p
<div><p>The GRMD (Golden retriever muscular dystrophy) dog has been widely used in pre-clinical tria...
<p>Group average change from initial body weight (top panels) and neurological disease severity scor...
International audienceIn the translational process of developing innovative therapies for DMD (Duche...
<p>The three graphs represent the evolution of the stride length normalized by the height at withers...
<p>This graph represents the evolution of the serum CK in the treated dogs (green curves) in functio...
<p>Position of the treated dogs (green own symbols) on the reference PCA plane defined by 18 adult G...
<p>Box-and-whisker plots of TSCIS motor score on day 42 by treatment group, stratified by MFS at adm...
<p>(A) The trends of motor decline versus genotype, as judged by linear fits of the averages. Motor ...
<p>The results of relative maximal tetanic force (top graphs: A to C) and of the fatigue index (bott...
<p>The main clinical signs observed in GRMD dogs during treatment with bortezomib (three, four and f...
<p>(A) The mean (± SE) hindlimb grip strength for Crush (grey circles) and Sham (black circles). (B)...
(A) Total grading scores of clinical manifestation and (B) spontaneous locomotor activity at differe...
Dogs suffering from Golden Retriever muscular dystrophy (GRMD) present symptoms that are similar to ...
Background: This study aimed to measure the gait abnormalities in GRMD (Golden retriever muscular dy...
<p>The calculation method of the relaxation variables is schematized in the figure A. Figures B and ...
<div><p>The GRMD (Golden retriever muscular dystrophy) dog has been widely used in pre-clinical tria...
<p>Group average change from initial body weight (top panels) and neurological disease severity scor...
International audienceIn the translational process of developing innovative therapies for DMD (Duche...
<p>The three graphs represent the evolution of the stride length normalized by the height at withers...
<p>This graph represents the evolution of the serum CK in the treated dogs (green curves) in functio...
<p>Position of the treated dogs (green own symbols) on the reference PCA plane defined by 18 adult G...
<p>Box-and-whisker plots of TSCIS motor score on day 42 by treatment group, stratified by MFS at adm...
<p>(A) The trends of motor decline versus genotype, as judged by linear fits of the averages. Motor ...
<p>The results of relative maximal tetanic force (top graphs: A to C) and of the fatigue index (bott...
<p>The main clinical signs observed in GRMD dogs during treatment with bortezomib (three, four and f...
<p>(A) The mean (± SE) hindlimb grip strength for Crush (grey circles) and Sham (black circles). (B)...
(A) Total grading scores of clinical manifestation and (B) spontaneous locomotor activity at differe...
Dogs suffering from Golden Retriever muscular dystrophy (GRMD) present symptoms that are similar to ...
Background: This study aimed to measure the gait abnormalities in GRMD (Golden retriever muscular dy...
<p>The calculation method of the relaxation variables is schematized in the figure A. Figures B and ...
<div><p>The GRMD (Golden retriever muscular dystrophy) dog has been widely used in pre-clinical tria...
<p>Group average change from initial body weight (top panels) and neurological disease severity scor...
International audienceIn the translational process of developing innovative therapies for DMD (Duche...