NAbs binding to Aβ conformers and overlapping peptide fragments.

<p>The antibody binding curves are representative of Aβ fibril-isolated (<b>A</b>) and column flow through (depleted) (<b>B</b>) IVIg fractions against plate-immobilized Aβ conformers and overlapping Aβ peptide fragments, respectively. The data symbols represent antibody binding to the Aβ peptides specified in Panel C. (<b>C</b>) Schematic comparison of Aβ fibril-isolated and flow through IVIg fractions, as well as an anti-Aβ N-terminal mAb, 6E10, binding to the plate-immobilized Aβ conformers and overlapping peptide fragments.