Impaired FC in aging (Thy1)-h[A30P]αSYN mice.

<p>The indicated groups of mice were trained and after 24 h assessed for context learning (A) and after another 6 h for cued learning (B). Compared to non-shocked control mice (light bars), age-matched old trained wild-type (wt) mice (gray bars) showed highly significant reductions of exploratory behavior in response to both context and cues. Young (Thy1)-h[A30P]αSYN transgenic (tg) mice (green bars) showed almost normal FC for context and showed significantly reduced exploratory behavior in cued FC when compared to old transgenic mice (yellow bars). The old transgenic mice showed much reduced context FC and no cued FC at all. ***p<0.0001; **p<0.01.